Fachbeiträge Online 
"Dermatologische Untersuchungen zur Alopezieproblematik bei Rhesusaffen
(Macaca Mulatta) in verschiedenen Haltungsformen."
Verh. ber. Erkrg. Zootiere, 39, 411-418, (1999)
(Steinmetz H. P., Kaumanns W., Dix I., Müller E., Kaup F-J.)
"Fallbeschreibung eines PRA-Gen-Trägers bei Irish Settern in Deutschland."
Kleintierpraxis, 1999, Vol 44, Iss 3, pp 211-212 (B. Zuleger, P. Kühnlein, E. Müller.)
Title: A case-report on a carrier of the PRA-causing mutation in Irish Setters in Germany.
Abstract: In contrast to other breeds the PRA-causing gene mutation (rcd1-mutation) is known for Irish Setters. By testing 52 dogs for this rcd1-mutation one dog was found to be positive. This is the first report on an Irish Setter being a PRA-carrier in Germany.
"Therapieerfolg durch Anwendung von Autovakzinen bei verschiedenen Krankheits-
bildern von Hunden, Katzen und Pferden - Erfahrungen aus der Praxis."
Kleintiermedizin, 5/1999; pp 192-196 (Klein, B. U., Heusinger, A., Müller, E.)
"Die Rolle obligat anaerober Bakterien bei Infektionen kleiner Haustiere.
Vorkommen, Diagnose und Resistenzentwicklung"
Tierarztliche Praxis Ausgabe Kleintiere Heimtiere, 1999, Vol 27, Iss 3, pp 156-161
(Klein, B. U., Müller, E.)
Title: The role of obligate anaerobes in infections of small animals. Occurrence, diagnosis and development of resistance.
Abstract: 968 samples of clinical specimens from various origin with suspicion of anaerobic infection were examined for the occurrence of obligate anaerobes. 556 samples showed cultural growth of germs, in 23% thereof anaerobes were detected. In 9% of these samples only anaerobes were found. When looking for aerobes/facultative anaerobes alone, these samples would have been culturally negative. These data show the relevance of the specific examination for anaerobes in case of suspicion for this type of infection. The germs most often isolated were gramnegative rods (67%), 30% of all isolates were Bacteroides sp. Isolates of Bacteroides fragilis-group have increased to 19% of all isolates in comparison to similar former surveys. This fact is of great clinical relevance because the Bacteroides fragilis-group is mostly responsible for the increase of resistance within the group of anaerobes. Besides, we found an increase of resistance with Fusobacterium sp. And Prevotella sp. Similar results were found in studies in humans. Good results for therapy can be expected with amoxicillin potentiated by clavulanic acid. Despite the importance of the present retrospective study for the choice of an antibiotic for initial therapy until results from a laboratory are available, the clinician should not renounce on a resistance testing. The predictability of the resistance of obligate anaerobes belongs to the past.
"Bakterielles und mykologisches Keimspektrum und Resistenzverhalten
bei der Otitis externa von Hunden und Katzen."
Kleintierpraxis, 1999, Vol 44, Iss 1, pp 27-33 (Klein, B. U., Müller, E.)
Title: Bacteriological and mycological germs and their resistance patterns isolated in otitis externa of dogs and cats
Abstract: 406 swab specimen from the ear channel of dogs and cats were microbiologically examined. 91% of samples were of dogs, 9% of cats. In 70% of all animals the bacteriological examination was positive, whereas in mycology 43% were found positive. In cases of otitis externa which were examined both bacteriologically and mycologically (n = 303), 90% of animals showed a positive result in culture. These numbers demonstrate the great relevance of a microbiological examination when otitis externa is present. The examination should be started soon after diagnosing the disease to avoid the state of chronicity. In our study, cats showed another spectrum of germs in bacteriology than dogs. To show the antibiotic with the best activity against single germs most easily, we presented the results of our resistance testing as a ranking of the tested antibiotics. For all germs isolated from dogs the order of ranking was: gentamicin (19 % resistant) - enrofloxacin (21%) amoxicillin with clavulanic acid (24%) (n = 372 strains). For cats the order of ranking was: gentamicin (1%) - amoxicillin with clavulanic acid (10%)- cephalexin (12%) - enrofloxacine (29%) (n = 41 strains). Malassezia pachydermatis was isolated in 44% of the dogs and 27% of the cats. All strains (n = 52) were examined for their state of resistance. Ketoconazole and econazole showed best activity against Malassezia pachydermatis in vitro. The results of thisstudy advice the clinician to keep a stock of preparations for the treatment of otitis externa and to look for therapeutic alternatives.
"Möglichkeiten und Grenzen dermatologischer Ergänzungsuntersuchungen Im Labor"
Hautkrankheiten beim Pferd, Arbeitsgruppe Pferd, Basis und Praxiswissen über Pferde,
Band 10, Dr. Arno Lindner (Hrsg.), 1999 ( Loesenbeck G.), ISBN 3-00-004312-8
"Vakzineassoziierte Sarkome bei Katzen."
Praktische Tierarzt, 1999, Vol 80, Iss 3, pp 176-181 (Loesenbeck G.)
Title: Vaccine-associated sarcomas in cats
Abstract: An association of vaccination in cats against leukosis and rabies and the development of sarcoma In vaccination-sites is most likely. Related to the amount of injections the incidence is low, 1 : 10.000 is suspected, The most important risk factor seems to he multiple vaccination in one site.
1998-1997
"Die Rolle von Oralstreptokokken als Indikatorkeime bei
Paradontalerkrankungen bei Hunden und Katzen."
Kleintierpraxis, 1998, Vol 43, Iss 12, pp 899-910 (Mihaljevic, S.-Y., Klein, B. U.)
Title: "Oral streptococci as indicator of periodontal disease in dogs and cats."
Language: German
Abstract: In 72 teeth healthy or from inflammation of the mouth region suffering dogs and cats,supragingival swab samples of the right P4 and M1 or of the most affected quadrant of the upper jaw were taken to examine microbiologically the streptococcal flora and accompanying germs. The aim of the study was to find out, whether Sc. Mutans is involved in the pathogenesis of periodontal diseases and, whether there is increased occurrence of certainstreptococci in relation to inflammatory processes of the mucosa of the mouth. Sc. Mutans was only identified in 3 % of the affected dogs, but neither in healthy dogs nor cats. In contrast, the isolation of Sc. Sanguis in affected dogs was significantly increased compared to healthy dogs. Within the group of affected dogs the frequency of isolation correlated with the degree of affection. The germs Sc. Bovis and Sc. Suis were most frequently identified. Among the accompanying germs Escherchia coli, Pseudomonas sp., staphylococci, and Pasteurella multocida were most often isolated. The occurrence of Pasteurella multocida in cats with inflammatory affections of the mucosa of the mouth was significantly higher than in healthy cats. We consider Sc. Mutans not relevant for the pathogenesis of periodontal diseases in dogs and cats. In contrast Sc. Sanguis can be considered as an indicator for periodontal disease in dogs. In cats no such indicator could be identified among streptococci. In this species, however the role of Pasteurella multocida should be elucidated in a bigger population. Taking into account the low frequency of isolation and the obviously missing relevance of Sc. Mutans in dogs, this species does not appear to be a suitable model for human caries research.
"Die Einsendung von Hautbiopsien zur pathohistologischen Untersuchung
- wie Sie Geldverschwendung vermeiden."
Prakt. Tierarzt 79,4,306-308,1998 (Loesenbeck G.)
"Opthalmologische Befunde im Zusammenhang mit verschiedenen Virusinfektionen
der Katze." Kleintierpraxis, 1997, Vol 42, Iss 11, pp 887-900
(Heider H.J., Pox C., Loesenbeck G., Egberink H.)
Title: Ophthalmological Findings in Association with Different Virus-Infections in the Cat
Abstract: A profound eye examination was done on 60 FIV-and 28 FeLV-infected cats as well as on 14 cats with FIP. For comparison, cats lacking these virus infections were also examined as controls. Ophthalmologic changes were detected in high frequency in the infected cats and in the control groups as well. Most of the lesions could be characterized as signs of intraocular inflammation. FIV-specific lesions could not be observed ophthalmologically. FeLV-specific lesions consisted in an ocular lymphosarcoma (3 cases), FIP-specific lesions in a generalized granulomatous chorioretinitis in one cat. Other signs of ocular disease, which were previously considered characteristic for the mentioned virus infections were also observed in the noninfected control-cats.
"Intraokuläre Metastase eines Bronchialkarzinoms bei einer Katze"
Tierärztliche Praxis, 1997, Vol 25, Iss 3, pp 271-274
(Heider H.J., Loesenbeck G., Heider E., Drommer W.)
Title: Intraocular Metastasis of a Pulmonary Adenocarcinoma in a Cat.
Abstract: A rare case of a ten-year-old neutered male Persian cat is described, in which metastasis of a pulmonary adenocarcinoma into the choroid of the right eye had led to visual impairment and major ophthalmoscopically detectable changes of the fundus. These were a generalized hyporeflectivity of the tapetal fundus due to retinal edema with multiple areas of retinal detachment and also severe edema of the papilla, furthermore an increased tortuosity and congestion of the retinal vessels. While the diagnosis of a primary lung tumor could be made intra vitam based on the result of an x-ray examination, the neoplastic nature of the fundic lesions could only be confirmed by histopathologic examination.
PMID: 9289890 [PubMed - indexed for MEDLINE]
1995-1996
[ - ] "Augenbefunde bei serologisch FIV (felines Immundefizienzvirus)-positiven Katzen. "
- Dtsch. Tierärztl. Wschr. 102, 339-378, Heft 9, (1995)
- Zentralbl Veterinarmed B. 1996 Jul;43(5):305-11.
(Loesenbeck G., Drommer W., Heider H.J.)
Title: "Immunohistochemical Findings in Eyes of Cats Serologically Positive for Feline Immunodeficiency Virus (Fiv)"
Journal of Veterinary Medicine Series B - Zentralblatt Für Veterinarmedizin Reihe B - Infectious Diseases and Veterinary Public Health, 1996, Vol 43, Iss 5, pp 305-311 (G Loesenbeck, W Drommer, HF Egberink, HJ Heider)
Language: German
Abstract: In this study the eyes of 15 cats in the terminal stage of FIV infection were examined. The findings were compared to those in cats, which were euthanized because of other infectious diseases or for non-infectious reasons. Thirteen FIV-infected cats showed an anterior uveitis by means of light microscopy. No accumulation of retinal lesions were found in FIV-infected cats compared to the other cats examined. Additionally, there were no indications of lesions caused by opportunistic infections. In the posterior segments of the eyes, immunohistochemical examinations proved the plasma proteins C3 and IgG to be predominantly intravascular. The eyes of 11 serologically FIV-positive cats were available for immunohistochemical examination. In all 11 cats at least one of the plasma proteins C3 or IgG could be detected in the extravascular tissue of the anterior uvea. The extravascular presence of plasma proteins within the tissue seemed to be caused by an increased permeability of the vessels due to inflammation. Furthermore, the similar extravascular distribution pattern of IgG and complement component C3 in four cases indicated that immune complexes may play a role in the anterior uveitis of FIV-infected cats.
PMID: 8779812 [PubMed - indexed for MEDLINE]
1994
[ - ] "Borreliose des Hundes - Klinische und serologische Parameter"
Kleintierpraxis 39. Jahrgang, Heft 6 (1994) S. 375-380
(Dr. Elisabeth Müller)
Title: "Borreliosis in Dogs - Clinical and Serological Parameters." Language: German
Abstract: 344 sera of dogs with suspected borreliosis were examined by use of an indirect immunofluorescence test. Of these, 16 % were considered to be in a questionable range (titer of 1:64) and 15 % to be positive (titer of >1:64). In the group of positive animals two breeds seemed to be overrepresented (Bernese Mountain dogs, German shepherd dogs). Clinical symptoms most often seen were lameness, fever and apathy. Recovery after antibiotic treatment correlated with a significant decrease of the antibody titers within one to three months.
[ - ] "Microbiological Results of Ear Swabs from Dogs and Cats"
Tierärztliche Praxis, 1994, Vol 22, Iss 1, pp 80-84
(E. Müller, A. Heusinger)
Abstract: 413 swabs of dogs and cats ears were examined microbiologically. Bacteria could be isolated in 82% and yeasts or moulds in 28% of the cases. The most common bacteria species were coagulase-positive Staphylococci, Pseudomonas spp., beta-hemolytic streptococci, and Proteus spp. With Staphylococci being the most common isolate. Within the group of yeasts and moulds Malassezia pachydermatis was isolated most frequently (90%). From the results of in vitro antibiotic tests, a general recommendation for the treatment of otitis externa nonparasitaria could not be given. There were no significant differences in total faecal mass (placebo 399.4 g/72 h; cisapride; 414.5 g/72 h), faecal water content (placebo; 75.6%: cisapride 76.2%), or faecal excretion of fat (placebo; 12.7 g/72 h: cisapride; 11.6 g/72 h) and total bile acids (placebo; 2212 mumol/72 h: cisapride; 2261 mumol/72 h). The side-effects reported during placebo were constipation (n = 3), and during cisapride meteorism (n = 4) and increased appetite (n = 2). The increased stool frequency during cisapride treatment is not caused by malabsorption of water, fat, or bile acids, but seems to be the consequence of a direct motor effect.
PMID: 8165666 [PubMed - indexed for MEDLINE]
1989
[ - ] "The effect of cisapride on defaecation in normal human subjects-
lack of effect on faecal excretion of water, fat, and bile acids."
Aliment Pharmacol Ther. 1989 Dec;3(6):547-52.
(Berger V, Armbrecht U, Heusinger A, Wienbeck M, Stockbrügger R.)
Abstract: In order to elucidate whether or not the increased stool frequency that occurs during cisapride treatment is a result of malabsorption of water, fat, and bile acids, 12 healthy volunteers were dosed with either tablets of placebo q.d.s. or tablets of 10 mg cisapride q.d.s. during two periods of 5 days in a double-blind, crossover study. Stool frequency, stool consistency, and side-effects were recorded each day. Total faecal mass, faecal water content, and faecal excretion of fat and bile acids were determined during the last 72 h of each study period. Mean daily stool frequency was 18.8% higher during cisapride [1.68 +/- 0.12 (S.E.M.)] administration than during placebo (1.42 +/- 0.12); P = 0.038. The stool consistency score increased by 11.8% towards softer stools during cisapride dosing (N.S.). There were no significant differences in total faecal mass (placebo 399.4 g/72 h; cisapride; 414.5 g/72 h), faecal water content (placebo; 75.6%: cisapride 76.2%), or faecal excretion of fat (placebo; 12.7 g/72 h: cisapride; 11.6 g/72 h) and total bile acids (placebo; 2212 mumol/72 h: cisapride; 2261 mumol/72 h). The side-effects reported during placebo were constipation (n = 3), and during cisapride meteorism (n = 4) and increased appetite (n = 2). The increased stool frequency during cisapride treatment is not caused by malabsorption of water, fat, or bile acids, but seems to be the consequence of a direct motor effect.
PMID: 2518868 [PubMed - indexed for MEDLINE]
[ - ] = nicht mehr verfügbar / no longer available /
